Protein name:
Pleckstrin homology domain-containing family G member 6 (PH domain-containing family G member 6) ;
Alternative:
Myosin-interacting guanine nucleotide exchange factor (MyoGEF) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with MYH10. Interacts with ELMO1 and EZR (in an open conformation).
Function:
Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis.
Subcellular Location:
Cytoplasm
Cytoplasm
cytoskeleton
spindle
Cytoplasm
cytoskeleton
spindle pole
Cleavage furrow
During mitosis, localizes to the spindle pole, central spindle and cleavage furrow. In epithelial cells, recruited to the apical membrane by EZR.
Protein Attributes:
50:
MKAFGPPHEG | PLQGLVASRI | ETYGGRHRAS | AQSTAGRLYP | RGYPVLDPSR |
100:
RRLQQYVPFA | RGSGQARGLS | PMRLRDPEPE | KRHGGHVGAG | LLHSPKLKEL |
150:
TKAHELEVRL | HTFSMFGMPR | LPPEDRRHWE | IGEGGDSGLT | IEKSWRELVP |
200:
GHKEMSQELC | HQQEALWELL | TTELIYVRKL | KIMTDLLAAG | LLNLQRVGLL |
250:
MEVSAETLFG | NVPSLIRTHR | SFWDEVLGPT | LEETRASGQP | LDPIGLQSGF |
300:
LTFGQRFHPY | VQYCLRVKQT | MAYAREQQET | NPLFHAFVQW | CEKHKRSGRQ |
350:
MLCDLLIKPH | QRITKYPLLL | HAVLKRSPEA | RAQEALNAMI | EAVESFLRHI |
400:
NGQVRQGEEQ | ESLAAAAQRI | GPYEVLEPPS | DEVEKNLRPF | STLDLTSPML |
450:
GVASEHTRQL | LLEGPVRVKE | GREGKLDVYL | FLFSDVLLVT | KPQRKADKAK |
500:
VIRPPLMLEK | LVCQPLRDPN | SFLLIHLTEF | QCVSSALLVH | CPSPTDRAQW |
550:
LEKTQQAQAA | LQKLKAEEYV | QQKRELLTLY | RDQDRESPST | RPSTPSLEGS |
600:
QSSAEGRTPE | FSTIIPHLVV | TEDTDEDAPL | VPDDTSDSGY | GTLIPGTPTG |
650:
SRSPLSRLRQ | RALRRDPRLT | FSTLELRDIP | LRPHPPDPQA | PQRRSAPELP |
700:
EGILKGGSLP | QEDPPTWSEE | EDGASERGNV | VVETLHRARL | RGQLPSSPTH |
750:
ADSAGESPWE | SSGEEEEEGP | LFLKAGHTSL | RPMRAEDMLR | EIREELASQR |
790:
IEGAEEPRDS | RPRKLTRAQL | QRMRGPHIIQ | LDTPLSASEV |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human PH domain-containing family G member 6
ELISA Kit for Human PH domain-containing family G member 6
CLIA Kit for Human PH domain-containing family G member 6
CLIA Kit for Human PH domain-containing family G member 6
Polyclonal Antibody for Human PH domain-containing family G member 6
Polyclonal Antibody for Human PH domain-containing family G member 6
Monoclonal Antibody for Human PH domain-containing family G member 6
Monoclonal Antibody for Human PH domain-containing family G member 6
Protein for Human PH domain-containing family G member 6
Protein for Human PH domain-containing family G member 6
R&D Technical Data
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Precision
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Recovery
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT THR-35
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
Mural R.J.
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT THR-35
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH MYH10;SUBCELLULAR LOCATION
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH ELMO1 AND EZR;SUBCELLULAR LOCATION;MUTAGENESIS OF ASN-351
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CSPP1